Get Your “Rare Wonder” Limited Edition Custom Photo Ornament-Donate Today!

nonprofit autoinflammatory

The new Autoinflammatory Alliance “Rare Wonder” photo ornament!

The Autoinflammatory Alliance is very pleased to have our new 2015 Holiday Ornament in stock! We will be sending these customizable “Rare Wonder” snowflake photo ornaments to all our donors that have contributed generously this year, volunteered their time, or have done a fundraiser to support our organization to show our thanks.  These cute, limited edition snowflake ornaments will be sent to anyone that makes a donation before January 1st of at least $10 for one ornament in the US ($15 for international to cover shipping) or you can get 2 ornaments for a $15 minimum donation.

This large, shatterproof snowflake ornament is inscribed in silver with “Rare Wonder” on one side, and you can put in your own photo to honor the loved ones in your life with autoinflammatory, or any rare disease!  The custom photo area is over 2 inches in diameter, and you can even feature a photo on each side.

Use this link to make your donation on paypal, and we will send you your ornament before the New Year!  These are something that you can display throughout the winter, and even for Rare Disease Day on February 29, 2016!

All donations will help us greatly, and are tax-deductible in the United States. Thank you!

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This is the third ornament in our series. The “One in a Million” heart ornament was our first, in 2013, then in 2014 we had the “Shine On-You’re One in a Million” star, and this year, we have the “Rare Wonder” photo ornament.

Make sure to donate right away, since we tend to run out of these ornaments fast!  Even though they are coming out at the end of the year, they will be great gifts for the rest of the season.

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Make a donation by the end of 2015 to get this ornament!

Donate here to get your ornaments while they last!

My Story – Living with TRAPS, a Rare Genetic Autoinflammatory Disease

adult living with traps periodic fever syndrome

For 64 years, Carol did not know the cause of her unexplained recurrent fevers and other debilitating symptoms, but despite that her life has been, and continues to be, full of adventures.

I have been blessed with a happy life.  My story is meant as a message of hope for all, but especially for patients with autoinflammatory diseases.

As the youngest of six children growing up in rural Vermont, I always knew I was different.  At the age of nine months I was hospitalized for several days with an unexplained high fever.  Throughout my life I have experienced recurring flares of high fevers, abdominal pain, vomiting, painful red rashes, muscle pains, etc.  I missed a lot of school, but luckily I was a good student, and stayed on top of my studies. When I was feeling well, I did all the normal kid things– I rode my bike, went to the community pool, skied, did sleep overs, went to camp, etc.  Early on, my parents gave up on main stream medicine and I saw a chiropractor.  I might add, no one else in my family exhibited any signs of illness.

Although it took me longer than four years, I graduated with honors from the University of Southern Maine with a B.S. in Business and Economics. When I married my husband in 1975, I inherited a fabulous family including two step-daughters.  As years went on, we added a special son-in-law and entered grandparenthood with five beautiful grandchildren.

By this time, I was dealing with additional symptoms with my flares, including eye issues (episcleritis, marginal keratitis), trigeminal neuralgia, and episodes of hives. The stomach aches left me doubled over in pain and in bed for two days or more.  I also experienced many urinary tract infections and a kidney infection.  Somehow, I soldiered on.

traps periodic fever syndrome adults

Walking the Great Wall of China is one of Carol’s many adventures. At the age of 64 with genetic testing, she learned what her mystery medical condition is. She has TRAPS (tnf receptor-associated periodic fever syndrome).

At the age of 64, after a lifetime of struggling with my unknown, chronic and sometimes debilitating illness, I was diagnosed at the Mayo Clinic in Scottsdale, AZ with TRAPS.  When I received the genetic results in April of 2011, I wept.  I was validated, and I finally had a name to all my bizarre symptoms! I have been hospitalized four times, and sent to multiple specialists–including a trip to Boston, from Maine where we live. I have endured a zillion tests–not always pleasant.  There was never an answer, although I never gave up hope. I was a mystery until the Mayo Clinic.

Carol with Muhammad Ali.

Carol with Muhammad Ali.

My illness has not defined me, or controlled my happiness and my life.  I decided early on to live my life, and have chosen to take a positive approach to live well.  I have learned to adapt by focusing on what I can control – eating a healthy diet, exercising, learning to say “no,” seeking support from friends and family, and actively participating in decisions about which doctors to see and my treatment.  For multiple reasons at this time, I have decided to stick with prednisone for my flares.

I also worked part-time for decades, as needed, and when I was physically able for one of Maine’s largest general contractors.  I even worked at the 1980 Lake Placid Winter Olympics.  Some fun and memorable life experiences come to mind: Spending an afternoon with Muhammad Ali at his training camp in PA; having a white knuckle glider plane ride in Peoria, AZ, and a helicopter ride (up front with the pilot) into the Grand Canyon; 1994 attendance of the NCAA Final Four in San Antonio, TX; and lastly–making a cameo appearance in the filming at our home in Portland, ME for the television show “America’s Most Wanted.”  It was a reenactment of a story. I have traveled extensively, including Alaska and I cruised the Panama Canal, walked the Great Wall in China, held a koala bear in Australia, and attended a family wedding in New Zealand.  There are many more places I have visited and more on my “Bucket List” that I would love to visit.

autoinflammatory diseases adults

Carol with her bonus grandchildren she met through her work with the Refugee Resettlement Center in ME.

I volunteered for many years for the Refugee Resettlement Center in Portland, ME as an American friend and a tutor to new arrival families from Azerbaijan, Bosnia, Vietnam, and other countries. Many became part of our family. I discovered, through volunteering that others have a very different kind of struggle. Somehow, my struggle seemed less significant than coping with a language barrier, limited employment opportunities, and adjusting to a new country and new culture.  I learned that perspective really does make a difference.

Although any disease can be challenging, there is a silver lining in every cloud.  Find gratitude and joy in your blessings.  Live life!!

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Carol married in 1975. Their family now includes 5 grandchildren!

Click here to learn more about TRAPS.

Click here to learn What is a Periodic Fever Syndrome?

Periodic Fever Syndromes in Adults

periodic fever syndromes in adultsUpdated 6/11/21

Autoinflammatory diseases, also commonly known as periodic fever syndromes, are systemic inflammatory diseases caused by malfunctions of the innate immune system. Most autoinflammatory diseases are genetic chronic lifelong diseases that typically have the first symptoms start in childhood. However, due to the complex range of symptoms and their rarity, patients with these conditions may not get diagnosed or effective treatment until they are adults. And in some cases, the first symptoms don’t appear until adulthood.

In addition, some patients may be diagnosed with autoinflammatory disease symptoms as a child, but the cause may not have been classified, or determined yet, and these patients are still seeking a diagnosis, often into adulthood.  Experts on autoinflammatory diseases estimate that up to 2/3 of their patient population has a systemic undifferentiated autoinflammatory syndrome , so it is important to consider systemic autoinflammatory diseases as a possible diagnosis in a patient that has the following symptoms, even if the genetic cause has not yet been identified or symptoms started in adulthood.

Typical Autoinflammatory Symptoms and Lab Results

Symptoms vary between the different autoinflammatory syndromes, but there are some common symptoms that many share:

adults periodic fever syndrome

Severe abdominal pain is a common symptom of some fever syndromes, such as FMF and HIDS. Patients may have a history of being misdiagnosed with appendicitis and/or food poisoning.

  • recurrent fevers (without an infectious cause; may occur every month or randomly)
  • rashes
  • joint pain and/or arthritis
  • mouth ulcers
  • gastrointestinal symptoms including vomiting and/or diarrhea
  • stomach or chest pain
  • red eyes (non-infectious conjunctivitis)–some may even get uveitis and/ or iritis (inflammation in the eyes)

Many autoinflammatory diseases have similar lab results including:

  • high inflammatory markers (CRP, ESR, SAA)
  • high WBC
  • most have negative ANA and other autoantibody tests

Some autoinflammatory diseases cause chronic inflammation that can affect any organ system in the body over time. This includes:

  • sensorineural hearing loss
  • enlarged liver and/or spleen
  • bone involvement
  • secondary amyloidosis
  • aseptic meningitis (either during flares or chronically, depending on the autoinflammatory disease)
  • Gastrointestinal inflammation, ulcers, or perforations

Depending on the syndrome, many will have flares of symptoms that can last for a few days to several weeks, while some will have continuous inflammatory symptoms. Between flares, some patients may be asymptomatic with normal lab values. But for those with mild to moderate chronic symptoms, even when they do not have a fever, they may have elevated inflammatory markers, other abnormal labs and/or symptoms related to chronic inflammation.

It’s important to note that the above list represents the most common presentation of many autoinflammatory diseases, but there are some who do not have typical symptoms.

It is essential that physicians consider autoinflammatory diseases as a possible diagnosis when they are presented with a patient who has recurrent fevers or other signs of systemic inflammation, especially since childhood, along with other symptoms such as rash and/or arthritis.  With genetic testing and resources to compare symptoms, doctors should be able to diagnose, and treat more patients.

Many Adults are Still Misdiagnosed and Suffering

Some adult specialists may see patients who were not properly treated for their disease throughout their life who have developed the most severe complications associated with their disease. This is because many patients come into adulthood without an accurate diagnosis and/or correct treatment due diagnostic challenges. Some of these challenges include these being rare diseases with a lack of information on these diseases in medical school, many being newly discovered diseases, and some patients not presenting as a textbook case making diagnosis difficult.

Most of the autoinflammatory diseases have had their genetic cause discovered in the past 15-20 years.  In addition, thanks to genetic testing and collaboration by experts worldwide, many newly classified autoinflammatory diseases have been identified in the past 15 years or less, so many patients that were previously undiagnosed may get help now.

Also, these conditions may be easily missed in childhood and thought to be just recurring, typical childhood illnesses. With common symptoms, such as fever, the symptoms may not raise suspicion early on. Over time the symptoms and affects of systemic, chronic inflammation may be more apparent. Some conditions may go into remission for months to years at a time or the symptoms may change throughout life, which may make it difficult to notice a regular pattern for symptoms.

Some patients may have symptoms that are more pronounced, or debilitating as adults, but others may have their symptoms reduced, or present differently in adulthood. Some patients may not have the typical presentation for their disease, such has not having fevers, but can still develop severe complications such as amyloidosis. For example, there is a form of adult-onset familial Mediterranean fever (FMF) that the first noted symptom is amyloidosis in various organs of the body.

In Cryopyrin-associated Periodic Syndrome: CAPS Seen from Adulthood Dr. Isabelle Kone-Paut writes, in regards to CAPS that, “The diagnostic delay is deleterious to patients compromising their quality of life and exposing them to neurosensory complications and renal failure by secondary amyloidosis.”

Adult Patients Need Compassion from Medical Professionals

When patients come into an adult specialty practice after years of being undiagnosed, and untreated, or misdiagnosed and without proper treatment, they may have more damage and complications from their disease that needs expert care. In addition, many patients that reach adulthood without a diagnosis have endured great stigmas and challenges emotionally, and the affects of chronic illness can affect their ability to work, or obtain their full potential in education or a career. A number of adult patients may stop seeing doctors, as they have “given up” on doctors ever finding out what they have, or how to treat it, or have been told too commonly that “it’s all in your head.” Their loved ones are often the ones that push them to try one more time to get help for their disease.  So, it is essential to consider the needs of the patient on all levels, and address any unmet psychosocial concerns in a compassionate way with these patients.

adults with autoinflammatory syndromes

Genetic testing can help diagnose autoinflammatory diseases. Click here for information on genetic testing.

Genetic Testing

Genetic testing for known autoinflammatory diseases can help to accurately diagnose patients and help guide treatment. Many patients report they were first misdiagnosed before getting genetic testing. Reported prior misdiagnoses in autoinflammatory patients include: Cancer, allergies, Sjogren’s, leukemia, lupus, allergies, fibromyalgia, Crohn’s disease, immunodeficiency, infections, and appendicitis.

In the U.S. there are now several periodic fever panel genetic tests available that test for most all known fever syndromes at one time and at very reasonable cost.

Other Diagnostic Tools

Other tools that can help with diagnosing patients who are suspected of having an autoinflammatory disease include:

Autoinflammatory Search –The Systemic Autoinflammatory Diseases (SAID) Database – This database is based on the Comparison Chart of Systemic Autoinflammatory Diseases that was reated and edited by Autoinflammatory Alliance President Karen Durrant, RN BSN as a co-author on the chart and database with many leading experts on autoinflammatory diseases,. Here you can search for symptoms and lab results to get a list of autoinflammatory conditions to consider, and find many helpful resources and links to medical publications for each disease. This comparative chart has become a highly respected and important diagnostic tool for doctors and patients around the world, and this new search database is the most current, updated and easy to use method for learning about autoinflammatory diseases available at the moment.

Eurofever Classification Criteria – This quiz gives a risk score that a patient may have TRAPS, HIDS, FMF, or CAPS based on specific symptoms a patient has.

Also it’s essential that patients keep an accurate symptom log as the pattern of symptoms greatly helps with diagnosis. Click here for more symptom logs used by autoinflammatory patients.

Adult-onset Autoinflammatory Diseases as an Atypical Presentation

It is most common for these syndromes to start in childhood, however there are documented patients with adult-onset symptoms with what are typically considered infant or childhood-onset fever syndromes. It’s important not to discount autoinflammatory diseases as a possibility just because the patient’s symptoms did not start in childhood.

For example, patients with FMF (familiar Mediterranean fever), HIDS (hyperimmunoglobulinemia D with periodic fever syndrome), TRAPS (tumor necrosis factor (TNF)-associated periodic syndrome), CRMO (chronic recurrent multifocal osteomyelitis), DITRA (deficiency of interleukin-36 receptor antagonist), and CAPS (cryopyrin-associated periodic syndromes, including: FCAS, Muckle-Wells and NOMID/CINCA) typically develop symptoms in early childhood, but all have reported some adult-onset cases. In CAPS, patients that do not present with symptoms until adulthood are often found to have either a variant genetic mutation for CAPS, or they may have somatic mosaicism, which occurs when the genetic mutation that causes disease is not found in all cells. Somatic mosaicism can be missed on standard genetic testing. In the past, 40% of patients with clinical symptoms of CAPS did not have their genetic mutation identified on standard testing, but when the newer, specialized tests were done, over 99% of those patients had their mutation found, and most had somatic mosiaicsm.

Dr. Lachmann et al reported in a 2014 study published in the Annals of Rheumatic Diseases that 22% of study participants had adult-onset TRAPS.

Adult-onset presentations of these diseases may have an atypical clinical presentation than childhood-onset. According to the authors of Clinical and genetic characterization of the autoinflammatory diseases diagnosed in an adult reference center published in Autoimmunity Reviews in 2015, “Compared to children, adult patients with AID in our series presented more frequently with non-severe manifestations and none of them developed amyloidosis during follow-up. Adult patients also carried higher proportion of low-penetrance mutations or polymorphisms and all genetic variants were presented in heterozygosis or as heterozygous compounds.”

A few Classified Autoinflammatory Diseases Start in Adulthood

A few autoinflammatory diseases are different in that they rarely or never start in childhood and most patients will not develop symptoms until they are adults. Some autoinflammatory diseases known to more commonly have symptoms start in adults include: Adult-onset Still’s disease (age 16 to 35 most commonly), Behçet’s (20s to 30s), and Schnitzler’s (most cases start in middle age at over 35 to 50 years old).

Fertility, Pregnancy, and Breastfeeding

Adult patients may have concerns about becoming pregnant and having a healthy pregnancy. Many patients with an autoinflammatory disease do have successful healthy pregnancies. However, some fever syndromes are associated with increased infertility and certain risks during pregnancy. In some cases, it’s been noted that having good treatment and control of the disease symptoms and inflammation reduces those risks.

Because of possible risks and complications before and during pregnancy, both the rheumatologist and obstetrician need to closely monitor autoinflammatory patients during pregnancy.

Fertility

There are very few studies regarding fertility and autoinflammatory diseases, but likely each syndrome affects fertility differently. The authors of the study Muckle-Wells syndrome and male hypofertility: a case series concluded that, “MWS may be associated with subfertility and infertility in male patients.” When left untreated, FMF is known to cause infertility in both men and women. The authors of the study No appreciable decrease in fertility in Behçet’s syndrome determined that infertility was not increased among Behcet’s patients.

pregnancy periodic fever syndromes

Many autoinflammatory patients have healthy pregnancies, however both the rheumatologist and obstetrician need to closely monitor patients during pregnancy.

Pregnancy

In some, but not all, autoinflammatory diseases, pregnancy does present some higher risks and complications for both the mom and baby. Patients with adult-onset Still’s disease have an increased risk for preterm birth and intrauterine growth retardation. FMF, when not treated increases the risk of miscarriage, premature birth, low birth weight in babies, and infertility in both men and women. Patients with Behçet’s disease have an increased risk for vascular complications, however one study noted that “neonatal outcomes were not negatively influenced by Behçets Disease.”

Having an autoinflammatory disease, however, does not guarantee that there will be problems with pregnancy. Some moms report that they felt the best they ever felt while pregnant because their disease went into remission during their pregnancy. The Autoinflammation website notes that in HIDS, “During pregnancy, attacks can disappear, but delivery can trigger an attack.”

At this time, any decision to use any medication during pregnancy or breastfeeding to treat an autoinflammatory disease in the mother is a strictly off-label, experimental use (not approved by the FDA or EMEA) for these medications.

The choice to use any medication should be made by the patient and their doctor.

It can be difficult making decisions about treatment during pregnancy. Some are fortunate to have fewer symptoms or even complete remission during pregnancy. For those who need treatment throughout pregnancy, there is limited information on the safety of commonly used medications for these diseases. Most biologics have not been studied for safety during pregnancy in autoinflammatory patients, however there are a few small studies where anakinra was used either daily or intermittently in pregnant autoinflammatory patients. These patients were better able to control their disease symptoms with treatment and most had otherwise healthy pregnancies and babies. Adverse events that did occur, such as renal agenesis, were not conclusively related to the use of anakinra. In some cases, the adverse event was a known risk associated with the mother’s autoinflammatory disease.

The authors of Brief Report: Anakinra Use During Pregnancy in Patients With Cryopyrin-Associated Periodic Syndromes concluded that continuing treatment of CAPS women during pregnancy with anakinra, “provided significant, persistent symptom relief while continuing to prevent the long-term sequelae of CAPS.”

Colchicine, the most effective treatment for FMF, has been used in pregnant women, in various reports for over 30 years. However, colchicine is listed as a class C medication by the FDA so it is important to discuss the use of medication during pregnancy with a physician.

A number of medical journal reports have found that in patients with FMF that have taken colchicine during pregnancy, that there were no significant negative effects in the infants, and the pregnant FMF patients also had a good outcome. According to the National Amyloidosis Centre in regard to FMF patients, “The chances of successful pregnancy outcome are actually better in patients who are careful to take their colchicine.”

This 2010 study found that colchicine had no impact on pregnancy and reported that, “Treatment with colchicine during pregnancy in patients with FMF is beneficial in controlling the disease while not affecting the outcome of the pregnancy.”

We have more studies on autoinflammatory treatments, pregnancy, and breastfeeding here. 

Breastfeeding

Colchicine has had a limited number of studies of use while breastfeeding. Colchicine does appear in human breast milk, at the same level as found in the mother’s plasma. There have been no signs of serious complications in infants that breastfed from mothers that were taking colchicine in various reports, but it is important to review the research findings, and discuss the options with a doctor. According to the drug information for colchicine on drugs.com:

“Limited information suggests that exclusively breastfed infants receive less than 10 percent of the maternal weight-adjusted dose. While there are no published reports of adverse effects in breast-feeding infants of mothers taking colchicine, colchicine can affect gastrointestinal cell renewal and permeability. The manufacturer warns that caution should be exercised when administering colchicine to breastfeeding women and their infants should be observed for adverse effects.”

According to Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk, Il-1ra (anakinra is an Il-1ra), is naturally secreted in higher amounts than in the blood into breastmilk in healthy individuals.  It is not currently known what the levels of anakinra are in human breast milk, or if drinking Il-1RA  from the milk is, or is not absorbed in the intestines. So it is important for patients to discuss the pros and cons or breastfeeding and the unknowns of anakinra use during breastfeeding with their doctor.  This same guidebook states,

“Because of the presence of native Il-1ra in milk, there appears to be no risk to a nursing infant from maternal administration of anakinra.”

Many Treated Patients Are Now Living Longer and Healthier Lives–But Still Have a Lot of Unknowns

In the last 30 years, research has led to great advancements in the diagnosis and treatment of patients with autoinflammatory diseases. Genetic testing has led to a better understanding of the causes and mechanisms leading to inflammation in patients with autoinflammatory syndromes.  Biologic medications that target the intracellular drivers of autoinflammation have helped many patients to have improved overall health, less flares or symptoms of their autoinflammatory disease, and reduced chronic inflammation.

Once fatal conditions, such as NOMID (neonatal-onset multisystem autoinflammatory disease) and DIRA (deficiency of interleukin-Iβ receptor antagonist), now have a better prognosis with these targeted treatments, especially if the patient is diagnosed and started on treatment early in life. Before targeted biologic treatments were available, 20% of patients with NOMID, the most severe form of CAPS (cryopyrin-associated periodic syndromes), did not survive into adulthood, and 100% of patients with DIRA died in early childhood, or infancy. Now these patients are living longer, and much healthier lives.

In the past, it was uncommon for many patients with the most severe autoinflammatory diseases to reach adulthood, so most adult rheumatologists or other physicians that only care for adult patients may not have encountered some of these rare, severe diseases, but these are lifelong conditions.  Some of the less severe patients may go for years or decades without a diagnosis, and may present with symptoms that they have been dealing with for their entire life to an adult rheumatologist. So it is essential that these specialists consider autoinflammatory diseases when presented with a case that features many of the symptoms listed at the beginning of this article, especially if the patient has recurrent fevers, and other symptoms such as rashes.

With patients that have started treatment for their autoinflammatory disease in early childhood, and have had their symptoms well-controlled with their medications, an adult rheumatologist may not see the severity of chronic damage, or many of the “classic” symptoms, because treatments may have prevented some or all of the complications typically associated with their condition. An extensive health history can help to identify the patient’s symptoms, and the extent that the disease has affected their health and quality of life.

For some of these conditions, such as DIRA, that if untreated is always fatal in early childhood, it’s unknown what health challenges and complications the adults may face. It is hopeful that more and more patients will be living longer and healthier lives. But their medical future is still uncertain, as there is little known about the health of adults with some of these these severe autoinflammatory diseases.

For all adult autoinflammaotry patients, there is a great need for more awareness of these syndromes by adult specialty physicians that may encounter autoinflammatory patients in their practice.

References

  1. RareConnect: TRAPS Infographic
  2. PubMed.gov: Familial Mediterranean Fever With Complete Symptomatic Remission During Pregnancy
  3. PubMed.gov: A retrospective survey of patients’ journey before the diagnosis of mevalonate kinase deficiency
  4. PubMed.gov: The novel S59P mutation in the TNFRSF1A gene identified in an adult onset TNF receptor associated periodic syndrome (TRAPS) constitutively activates NF-κB pathway
  5. PubMed.gov: Clinical and genetic characterization of the autoinflammatory diseases diagnosed in an adult reference center
  6. Reumatismo: Childhood versus adult-onset autoinflammatory disorders: myths and truths intertwined
  7. PubMed.gov: Caution Should be Used in the Recognition of Adult-Onset Autoinflammatory Disorders: Facts or Fiction
  8. Autoinflammatory Alliance: NOMID/CINCA
  9. PubMed.gov: Cryopyrine-associated periodic syndrome: CAPS seen from adulthood
  10. PubMed.gov: The phenotype of TNF receptor-associated autoinflammatory syndrome (TRAPS) at presentation: a series of 158 cases from the Eurofever/EUROTRAPS international registry
  11. PubMed.gov: Brief Report: Cryopyrin-Associated Periodic Syndrome Caused by a Myeloid-Restricted Somatic NLRP3 Mutation
  12. PubMed.gov: The expanding spectrum of low-penetrance TNFRSF1A gene variants in adults presenting with recurrent inflammatory attacks: clinical manifestations and long-term follow-up.
  13. PubMed.gov: Clinical and genetic characterization of the autoinflammatory diseases diagnosed in an adult reference center
  14. PubMed.gov: No appreciable decrease in fertility in Behçet’s syndrome
  15. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk
  16. PubMed.gov: Hyper-IgD syndrome and pregnancy
  17. PubMed.gov: Successful outcome of two pregnancies in patients with adult-onset Still’s disease treated with IL-1 receptor antagonist (anakinra)
  18. Wiley Online Library: Brief Report: Anakinra Use During Pregnancy in Patients With Cryopyrin-Associated Periodic Syndromes
  19. Pediatric Rheumatology: ANTI IL-1 therapies and pregnancy outcome
  20. BMJ.com: A patient’s wish: anakinra in pregnancy
  21. PubMed.gov: Adult-onsetl Still’s disease and pregnancy: about ten cases and review of the literature
  22. PubMed.gov: Behcet disease and pregnancy
  23. PubMed.gov: Retrospective evaluation of pregnancy outcomes in women with familial Mediterranean fever
  24. Amyloidosis.org: Colchicine in Pregnancy
  25. PubMed.gov: Muckle-Wells syndrome and male hypofertility: a case series
  26. PubMed.gov: Pregnancy outcomes in women with familial Mediterranean fever receiving colchicine: is amniocentesis justified?

*Adult fever photo by CandyBox Images

* Stomach pain photo by Yulia

* Pregnant photo by Bayu Aditya/Flickr