TRAPS

Tumor necrosis factor (TNF)-associated periodic syndrome (TRAPS) is a dominant condition caused by mutations ont he TNFRSF1A gene. It used to be referred to as familial Hibernian fever.

Common TRAPS symptoms include:

  • Fevers that last days to weeks with an average of 3 weeks
  • Migrating rash
  • Severe muscle pain (often under the rash)
  • Abdominal pain
  • Headaches
  • Conjunctivitis
  • Swelling around the eyes

The most effective treatment for TRAPS are the Il-1 inhibitor medications (anakinra and canakinumab usually). Ilaris (canakinumab) is now an FDA approved medication for the treatment of TRAPS.

Click here for an overview of TRAPS on the autoinflammatory database.

Fever length and some other symptoms of TRAPS are similar to TRAPS11. Learn more about TRAPS11 here.

Refer to our website for more information, and the rareconnect.org TRAPS community as another resource.

Also, we have compiled a list of helpful research articles about TRAPS in the post below:

List of TNF Receptor-Associated Periodic Syndrome (TRAPS) Research and Information