TRAPS11 was first identified in 2014. Symptoms are similar to TRAPS with recurring fevers that can last from 8 days to 5 weeks.
Below are links to helpful research and information about TRAPS11. This is not an all-inclusive list. For more, search Pubmed.gov.
In the U.S., the MNG Laboratories fever panel includes TRAPS11 genetic testing. Click here to find more genetic testing for TRAPS11.
Brief Report: Involvement of TNFRSF11A Molecular Defects in Autoinflammatory Disorders – This discusses 3 patients with TNFRSF11A mutations; their symptoms and genetic analysis. Symptoms noted included fevers of 8 days to 5 weeks, abdominal pain, pharyngitis, headaches and more. Age of onset ranged from newborn to 18 years old.
Newly recognized Mendelian disorders with rheumatic manifestations. – “Mutations in ADA2, TRNT1 and COPA, AP1S3, and TNFRSF11A cause complex syndromes; loss-of-function mutations in enzymes and molecules are linked to the generation of ‘cellular stress’ and the release of inflammatory mediators that likely cause the inflammatory disease manifestations.”
