Tag Archives: hids disease

High IgD in Periodic Fever Syndromes

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In 1984, Dr. Jos van der Meer published a study describing a newly recognized periodic fever syndrome. All six  patients in this study had similar symptoms of periodic fevers with other inflammatory symptoms. They also all had elevated immunoglobulin D. … Continue reading →

PFAPA vs. HIDS

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Updated 2/15/2022 HIDS (hyper-IgD syndrome, a mevalonate kinase deficiency) and PFAPA (periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis) are both periodic fever syndromes that generally start in childhood and have very similar symptoms. It can be difficult to distinguish … Continue reading →