List of TNFRSF11A-associated Hereditary Fever Disease (TRAPS11) Research and Information

TRAPS11 was first identified in 2014. Symptoms are similar to TRAPS with recurring fevers that can last from 8 days to 5 weeks.

Below are links to helpful research and information about TRAPS11. This is not an all-inclusive list. For more, search

In the U.S., the MNG Laboratories fever panel includes TRAPS11 genetic testingClick here to find more genetic testing for TRAPS11.

Brief Report: Involvement of TNFRSF11A Molecular Defects in Autoinflammatory Disorders – This discusses 3 patients with TNFRSF11A mutations; their symptoms and genetic analysis. Symptoms noted included fevers of 8 days to 5 weeks, abdominal pain, pharyngitis, headaches and more. Age of onset ranged from newborn to 18 years old.

Newly recognized Mendelian disorders with rheumatic manifestations. – “Mutations in ADA2, TRNT1 and COPA, AP1S3, and TNFRSF11A cause complex syndromes; loss-of-function mutations in enzymes and molecules are linked to the generation of ‘cellular stress’ and the release of inflammatory mediators that likely cause the inflammatory disease manifestations.”

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