There are several Autoinflammatory/periodic fever syndromes that have flares triggered by cold or cooling temperatures. These syndromes include cryopyrin-associated periodic syndromes (CAPS), such as familial cold autoinflammatory syndrome (FCAS) and Muckle-Wells syndrome (MWS), NLRP12/FCAS2, PLCG2-associated antibody deficiency & immune dysregulation … Continue reading →